Vitamin B12 is dependent on adequate biotin and folate status for optimal efficacy. The combination acts synergistically in homocysteine metabolism regulation, and complement each other in the methionine cycle. 

Role in nitrosative stress and antioxidant properties
Binds and neutralizes NO and peroxynitrite, mitigating nitrosative stress
Helps regulate NO formation and detoxifies harmful radicals • Scavenges reactive oxygen species (ROS), preserves glutathione, and reduces homocysteine-induced oxidative stress.
Essential roles
Red blood cell synthesis, nervous system function and myelin synthesis, cellular growth and DNA synthesis, mental health support, reduction of tiredness and fatigue.
Increased requirements
Diets, smoking, sport activities, growth phases, pregnancy, chronic stress.